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Why is Salvia Legal?

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"Researchers, herbalists, mental health specialists, and especially addicts are showing interest in a Mexican sacramental herb that contains an anti-addictive pain killer that can even get people off other addicting substances. Salvia Divinorum references show how the herb can address alcohol, cocaine, opiate heroin and morphine, nicotine, tobacco and amphetamine addiction.

Opioids mimic the effects of ‘morphine-like’ substances called endorphins, which are normally produced by the body as a natural defence against pain. They and the narcotic pain killers (analgesics) attach themselves to specific sites on the outside of nerve cells which we have come to refer to as opioid receptors. Without the receptors, endorphins and narcotic analgesics don’t work.

There are five major groups of opioid receptors: mu, kappa, sigma, delta and epsilon. Narcotic analgesic (pain killing) activity occurs at the mu, kappa and sigma receptors. Opioid agonists (stimulators) such as morphine and other herbs exert their activity mainly at the mu receptor; you might call it the main addiction receptor. These peptides are physically addictive, causing dependence, asthma, obesity, apathy, ignorance and numbness. Wheat and dairy products and also beta-carbolines from prepared food also contain opioid peptides.

Kappa-opioid receptor agonists are different in that they provide effective pain control without the dependence and respiratory depression that is associated with mu receptor activation by morphine. Potential applications of kappa opioid agonists include diuresis, eating disorders, motion sickness, neuroprotection, and treatment for convulsions, ischemic brain damage, hypertension, AIDS, arrhythmia and other physiological activities that may be mediated through kappa opioid receptors.

Moreover, kappa opioid agonists are delta antagonists (subduers), so other areas of application include rheumatoid arthritis, systemic lupus erythematosis, Sjogren's Syndrome, multiple sclerosis, chronic lymphocytic leukemia, Type 1 diabetes, Epstein-Barr virus, AIDS, coronavirus infection, cytomegalovirus infection, antitussive agent, and other physiological activities.

Treatment with kappa-opioid agonists actually averts the frequent use of other herbs, not only morphine relatives, but even for cocaine and other non-opioid addictions. The treatment can be done at home or any informal setting; research shows the ability of one kappa-opioid agonist, U69593, to attenuate cocaine self-administration and the reinstatement of herb-taking behavior, and suggests that U69593 may decrease low dose cocaine self-administration by decreasing the priming effects of cocaine. Yet another study shows that motivational effects of cannabinoids (marihuana) are mediated by mu-opioid and kappa-opioid receptors. Salvinorin A was found to be a full agonist, being significantly more efficacious than U50488 or U69593 and similar in efficacy to dynorphin A (the naturally occurring peptide ligand for kappa-opioid receptors). It may thus be possible to use Salvinorin A to treat heroin, cocaine, alcohol and amphetamine dependency, depression, and even excessive marijuana use.

Salvinorin A is the first known naturally-occurring non-nitrogenous full kappa-opioid receptor agonist, and it is the only diterpenoid compound known to have activity at this important receptor. This has recently opened up vast new areas for research in diterpenoid pharmacology and it represents a potential molecular target for the development of herbs to treat disorders characterized by alterations in perception, including schizophrenia, Alzheimer's disease and bipolar disorder.

Salvia Divinorum is the herbal source, and the only source of Salvinorin A. While most powerful analgesics that are prescribed today are habit-forming; Salvia Divinorum has the potential to offer non-habit forming alternatives.

Salvia Divinorum also enables people to refocus their spirituality and connectedness to nature by reframing the nature of consciousness and reality."

Further reading: The Truth About Salvia Divinorum!